|Workshop on Topology: Identifying Order in Complex Systems|
|Topic:||A topological predictor of protein compressibility|
|Affiliation:||University of Pennsylvania|
|Date:||Saturday, April 9|
|Time/Room:||5:00pm - 6:00pm/David Rittenhouse Laboratory Room A4, University of Pennsylvania|
A standard question in contemporary proteomics asks which properties of proteins may be directly inferred from their molecular structure. Using only X-Ray crystallography data (of the type which is cataloged in the Protein Data Bank), I will outline a method which accurately estimates the compressibility of a given protein. The method involves imposing a filtered simplicial structure around the atom centers, computing certain algebraic-topological invariants, and employing rudimentary statistical techniques. This is joint work with Marcio Gameiro, Yasu Hiraoka, Shunsuke Izumi, Miro Kramar and Konstantin Mischaikow.